Abstract
The effects of coumarin fractions obtained from angelica fruits (Archangelica officinalis Hoffm.) und parsnip fruits [Pastinaca sativa L. (Apiaceae)] on the growth of cancer cells HeLa-S 3 cultured in the dark were studied.
It was concluded that coumarin fractions in the concentration above 5 µg/ml inhibited
the growth of culture. The angelica coumarin fraction had a stronger effect on the
growth cells than the parsnip coumarin fraction. Ten various coumarins, from which
eight were isolated from fractions, showed the effect on the growth and colony forming
ability of HeLa cells. The proliferation inhibition of HeLa cells by these coumarins
is as follows: osthol > xanthotoxol > 4-methylaesculetin > isopimpinellin > bergapten
> xanthotoxin > imperatorin > coumarin > umbelliferone > 4-hydroxycoumarin.
