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Am J Perinatol 1983; 1(1): 43-46
DOI: 10.1055/s-2007-1000051
ORIGINAL ARTICLE

© 1983 by Thieme Medical Publishers, Inc.

Interaction of Caffeine and Continuous Distending Airway Pressure in Neonatal Apnea

Jacob V. Aranda, Eugene W. Outerbridge, Teresa Trippenbach
  • Developmental Pharmacology and Perinatal Research Unit, Montreal Children's Hospital Research Institute, and Departments of Pediatrics, Physiology, Pharmacology, and Therapeutics, McGill University, Montreal, Quebec, Canada
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Publication History

Publication Date:
04 March 2008 (online)

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ABSTRACT

The interactive effect of caffeine and continuous distending airway pressure was evaluated in two premature neonates with apnea. The application of a continuous negative pressure around the chest wall decreased minute ventilation in both infants and blunted the stimulatory effect of caffeine. This potential interaction should be considered if the desired effects of caffeine or distending airway pressure on apnea control are not achieved when they are used concurrently.

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