Effect of a New Immunosuppressant, FTY720, on Joint Allografts

Hiroshi Watanabe; Yoshiki Hamada; Tadahito Toshima; Koki Nagasawa; Yoshitake Sakano

doi:10.1055/s-2007-1000104

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J Reconstr Microsurg 1999; 15(4): 295-298
DOI: 10.1055/s-2007-1000104

ORIGINAL ARTICLE

Effect of a New Immunosuppressant, FTY720, on Joint Allografts

Hiroshi Watanabe, Yoshiki Hamada, Tadahito Toshima, Koki Nagasawa, Yoshitake Sakano

Department of Orthopaedic Surgery, Yamanashi Medical College, Japan

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Publication History

Accepted for Publication 1999

Publication Date:
08 March 2008 (online)

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ABSTRACT

The immunosuppressive effects of a new agent, FTY720, on joint allografts were studied histologi-cally in a rat model. Favorable results without side effects were obtained at a dose of 3.0 mg/kg/day. The authors believe that this agent is one of the most useful immunosuppressants in the reported experimental model.