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J Reconstr Microsurg 1998; 14(7): 491-498
DOI: 10.1055/s-2007-1000212
ORIGINAL ARTICLE

© 1998 by Thieme Medical Publishers, Inc.

Histologic Findings in Polyacrylamide‐Coated Polytetrafluoroethylene (PTFE) Arterial Grafts in the Rat Abdominal Aorta

Manabu Maeda, Akihiro Fukui, Toshifumi Nakamura, Yuji Inada, Susumu Tamai, Satomi Haga, Kouko Tatsumi, Hiroshi Yamamoto, Sakae Ogata, Hiroo Iwata, Yoshito Ikada
  • Departments of Orthopedic Surgery and Anatomy, Nara Medical University, and Research Center for Medical Polymers and Biomaterials, Kyoto University, Japan.
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Publication History

Accepted for publication 1998

Publication Date:
08 March 2008 (online)

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ABSTRACT

To improve cell attachment without inducing thrombogenesis, the authors coated the inner surface of polytetrafluoroethylene (PTFE) prostheses (I.D.: 1 mm; length: 10 mm; wall thickness: 0.5 mm; fibril length: 30 μm) with polyacrylamide (PAA), known to have a strong antithrombotic effect (PAA-PTFE). They implanted the prostheses into the abdominal aorta of rats, and retrieved them at intervals of up to 9 months. Graft healing was observed under light and scanning electron microscopy. All the inner surfaces of the grafts examined were barely covered with fibrin or platelets. The PAA-coated fibers had many projections, in contrast to the original PTFE prostheses. Neo-endothelium was observed to be directly attached to these structural fibers of the PAA-PTFE grafts. Restoration of the neointima was also observed in these vascular prostheses.