Horm Metab Res 1994; 26(1): 46-48
DOI: 10.1055/s-2007-1000771
Originals Clinical

© Georg Thieme Verlag, Stuttgart · New York

Antiandrogen Treatment with Spironolactone and Linestrenol Decreases Bone Mineral Density in Eumenorrhoeic Women with Androgen Excess

J. Preželj, A. Kocijančič
  • Medical Centre Ljubljana, Endocrinology, Ljubljana, Slovenia
Further Information

Publication History

1993

1993

Publication Date:
14 March 2008 (online)

Summary

Increased bone mineral density (BMD) has been reported in young women with androgen excess. To determine whether antiandrogen treatment in young women with androgen excess reduces BMD in these patients, the authors measured BMD before and a year after the beginning of antiandrogen therapy with Spironolactone and linestrenol in 17 consecutive androgenized patients (median age 22 years). After a year's treatment BMD declined in 15 out of 17 patients, the mean decrease - 0.032 g/cm2 (95% CI of the difference 0.016-0.048) - being highly significant (p<0.001). Androstenedione decrease was the only hormonal variable significantly correlating with BMD decrease (r = 0.5; p = 0.037) according to simple linear regression.

A decrease of BMD might become a key factor in deciding about the duration of antiandrogen treatment with Spironolactone in functional hyperandrogenemia.