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Horm Metab Res 1994; 26(4): 166-168
DOI: 10.1055/s-2007-1000803
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© Georg Thieme Verlag, Stuttgart · New York

Acute and Chronic Effect of Ethanol on the Occurrence of Alloxan Diabetes in Rats

K. Katsumata1 , K. Katsumata2  Jr. , Y. Katsumata3 , T. Ozawa
  • 1Katsumata Hospital, Nagoya, Japan
  • 2The Second Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan
  • 3The Department of Legal Medicine, Nagoya University School of Medicine, Nagoya, Japan
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Publication History

1993

1993

Publication Date:
14 March 2008 (online)

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Summary

We investigated the chronic and acute effect of ethanol on alloxan-induced diabetes in rats. When 1 ml/l00 g b.w. of 35% ethanol solution was intraperitoneally injected into rats l0 min before intramuscular injection of alloxan, the alloxan-induced diabetes was completely prevented at the alloxan dosis (150, 200 mg/kg b.w.) at which the disease is unfailingly induced in control rats. This finding confirmed the results of Heikkila, Burden and Cohen. On the other hand, when rats were given 10% ethanol solution instead of water for 40 straight days, alloxan at a dose of 130 or 140 mg/kg caused diabetes in all cases, whereas no controls developed diabetes. This demonstrable effect of the promotion of alloxan-induced diabetes by chronic alcohol administration was the exact opposite of the acute effect of alcohol. We discussed the contradictory action of ethanol in relation to the occurrence of alloxan diabetes in rats.

Key words

Ethanol - Alloxan - Rat