Cobalt-Catalyzed Synthesis of Tertiary Azides from α,α-Disubstituted Olefins under Mild Conditions Using Commercially Available Reagents

Abstract

The use of commercially available azide sources is presented for the cobalt-catalyzed hydroazidation reaction. α,α-Disubstituted olefins with a variety of functional groups were employed as substrates, providing tertiary azides in useful yields.

Key words

alkenes - hydroazidation - homogeneous catalysis - cobalt - silanes

References

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13

Co(BF₄)₂·6H₂O (6 mol%), ligand 2 (6 mol%), alkene (0.5 mmol), azide source (1.5 mmol), t-BuOOH (30 mol%), TMDSO (1 mmol), EtOH (2.5 mL).

14

All sulfonyl azides tested in the reaction were provided by Sigma-Aldrich.