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Syntheses of the Proposed Structures of Poison-Frog Alkaloids 179 and 207E and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors

Naoki Toyooka*a, Dejun Zhoua, Soushi Kobayashia, Hiroshi Tsunekia, Tsutomu Wadaa, Hideki Sakaia, Hideo Nemotoa, Toshiyasu Sasaokaa, Yasuhiro Tezukab, Subehanb, Shigetoshi Kadotab, H. Martin Garraffoc, Thomas F. Spandec, John W. Dalyc
a Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan
e-Mail: toyooka@pha.u-toyama.ac.jp;
b Institute of Natural Medicine, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan
c Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD 20892, USA