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Horm Metab Res 1993; 25(3): 149-151
DOI: 10.1055/s-2007-1002065
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© Georg Thieme Verlag, Stuttgart · New York

Rat Pineal Gland Suppresses the Injection Stress-Reactive ACTH Outflow

J. Milin1 , K. Djakovic-Svajcer2 , M. Demajo3
  • 1Dept. of Pathology and Histology
  • 2Dept. of Pharmacology and Toxicology, Medical Faculty, Novi Sad
  • 3Inst. of Nuclear Sciences, Dept. for Molecular Biology and Endocrinology, Vinca, Beograd, Yugoslavia
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Publication History

1992

1992

Publication Date:
14 March 2008 (online)

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Summary

The involvement of the pineal gland in the regulation of the initial ACTH reactive outflow to short-term stress inducement was studied. The stress trial, consisting of the subcutaneous saline injection in the animal hind leg, elicited ACTH release, the peak appearing in the 5th min followed by a rapid downturn to the prestress level in the 15th min. The higher ACTH level in the pinealectomized rats was monitored in the 5th min. The results obtained show the implication of the pineal gland in restricting the magnitude of the initial stress-reactive ACTH outflow.

Key words

Pineal Gland - ACTH Outflow - Injection Stress - Pinealectomy