Thyroid Hormone Restores Atrial Stretch-Induced Secretion of Atrial Natriuretic Peptide in Hypophysectomized Rats

N. Zamir; M. Slover; K. P. Ohman

doi:10.1055/s-2007-1002066

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Horm Metab Res 1993; 25(3): 152-155
DOI: 10.1055/s-2007-1002066

Originals Basic

Thyroid Hormone Restores Atrial Stretch-Induced Secretion of Atrial Natriuretic Peptide in Hypophysectomized Rats

N. Zamir¹ , M. Slover² , K. P. Ohman²

¹Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
²Department of Internal Medicine, University Hospital, Linkoping, Sweden

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Publikationsverlauf

1992

1992

Publikationsdatum:
14. März 2008 (online)

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Summary

Acute blood volume expansion caused a rapid and profound release of atrial natriuretic peptides (ANP) from cardiac atria. The stimulated release of ANP was markedly blunted (more than 50%) in hypophysectomized rats (8 days after surgery). Daily subcutaneous injections of thyroxine (30 μg/kg) to hypophysectomized rats for 7 days, completely restored acute volume expansion induced release of ANP. Our data suggest that thyroid hormone is required for ANP secretion in response to acute volume expansion.

Key words

Atrial Natriuretic Peptide - Thyroxine - Atrium - Pituitary Gland