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Horm Metab Res 1993; 25(6): 298-300
DOI: 10.1055/s-2007-1002103
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© Georg Thieme Verlag, Stuttgart · New York

Inhibition of Progesterone Action by a Factor in Human Follicular Fluid

R. Juneja, P. Kadam, A. L. Kadam, S. S. Koide
  • Center for Biomedical Research, The Population Council, New York, New York, U.S.A.
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Publikationsverlauf

1992

1992

Publikationsdatum:
14. März 2008 (online)

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Summary

A factor was found in human follicular fluid that blocked progesterone-stimulated net uptake of 45Ca2+ in human sperm and progesterone-induced maturation of Xenopus oocyte. The factor was partially purified by ultrafiltration through PM-10 membrane and gel filtration on Sephadex G-25 column. The active fraction is effective at a concentration of 200 μg/ml. The present findings suggest that hFF factor may regulate the metabolism of progesterone sensitive cells.

Key words

Progesterone Inhibitor - Follicular Fluid - Human Sperm - Xenopus Oocyte