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Horm Metab Res 1993; 25(8): 403-406
DOI: 10.1055/s-2007-1002132
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© Georg Thieme Verlag, Stuttgart · New York

Enhancement of DNA Polymerase β Activity in the Pituitary Gland by Hormonal Feedback

A. Nagasaka1 , S. Yoshida2 , Rumi Masunaga1 , S. Kato1 , Motoko Kotake1 , A. Nakai1 , T. Kawabe1 , T. Tsujimura3 , Asako Inagaki3 , K. Iwase3
  • 1Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi
  • 2Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Showa-ku, Nagoya, Japan
  • 3Department of Surgery, Fujita Health University School of Medicine, Toyoake, Aichi
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Publication History

1992

1993

Publication Date:
14 March 2008 (online)

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Summary

The activity of DNA polymerase β (β-enzyme) in bovine and rat pituitary glands was remarkably higher in the anterior than in the posterior lobe. In sucrose gradient centrifugation, the activity in the anterior lobe of the bovine pituitary gland appeared at the sedimentation constant, 3.3 S, while that of rat pituitary gland appeared at 3.3 S, 7.3 S and 12 S, respectively. The activity in each fraction increased in the anterior lobes of rat pituitaries that were stimulated to release TSH by decreased thyroid hormone levels induced by an antithyroid drug. These results suggest that the activity of the β-enzyme is high in the cells of the anterior lobe which are hyperfunctioned to produce pituitary thyreotrophic hormone and may be controlled by hormonal feedback regulation.

Key words

DNA Polymerase - Pituitary Gland - Hypothyroidism