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Horm Metab Res 1993; 25(10): 539-542
DOI: 10.1055/s-2007-1002170
Originals Clinical

© Georg Thieme Verlag, Stuttgart · New York

Effect of Zinc Treatment on Serum Thyroid Hormones in Uremic Patients Under Peritoneal Dialysis

F. Arreola1 , R. Paniagua3 , A. Pérez2 , S. Díaz-Bensussen1 , E. Junco1 , S. Villalpando1 , E. Exaire2
  • 1Hospital de Pediatría, Centro Médico Nacional
  • 2Hospital de Especialidades, Centro Médico La Raza, Instituto Mexicano del Seguro Social
  • 3Instituto Nacional de Cardiología I, Chávez, México, D.F., México
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Publication History

1992

1993

Publication Date:
14 March 2008 (online)

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Summary

In order to evaluate the effect of zinc (Zn) deficiency on thyroid abnormalities in chronic renal failure, a Zn supplement (l00 mg/day, p.o.) was given for four weeks to eight uremic patients under peritoneal dialysis. Zn supplementation increased plasma levels of TSH (5.8±0.7 to 7.4±0.7 mU/l, p<0.02), T4 (61.6±3.9 to 93.9±6.2 nmol/l, p<0.01), T3 (1.31±0.14 to 1.70±0.18 nmol/l, p<0.01) and Zn (7.23±0.45 to 12.27±0.76 μmol/l, p<0.01). A close correlation was found between changes in plasma levels of Zn and changes in TSH (r = 0.82), T4 (r = 0.55) and T3 (r = 0.64), suggesting that Zn deficiency may play a role in the biosynthesis or release of hormones of the hypothalamic-pituitary-thyroid axis in chronic renal failure.

Key words

Zinc - Thyroid Hormones - Uremia - Renal Failure - Dialysis