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Horm Metab Res 1992; 24(2): 78-81
DOI: 10.1055/s-2007-1003260
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Increase of Serum Somatomedin C in Hyperthyroid Patients With Pregnancy

S. Suzuki1 , T. Yamada1 , T. Shirota1 , T. Aizawa1 , M. Ishihara1 , K. Tomita2 , K. Kuma3 , K. Kamoi4
  • 1Department of Gerontology, Endocrinology and Metabolism, School of Medicine, Shinshu University, Matsumoto, Naganoken
  • 2Marunouchi Hospital, Matsumoto, Naganoken
  • 3Kuma Thyroid Clinic, Kobe
  • 4Department of Medicine, Nagaoka Red Cross Hospital, Nagaoka, Niigataken, Japan
Further Information

Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

In thyrotoxic women with pregnancy, serum somatomedin C (SmC) concentration was markedly elevated (mean±SD 13.57±4.66 U/ml) compared to thyrotoxic women without pregnancy (1.24±1.09 U/ml), non-pregnant euthyroid women previously treated for hyperthyroidism (0.87±0.30 U/ml), normal subjects with pregnancy (6.08±3.36 U/ml) and pregnant euthyroid women previously treated for hyperthyroidism (5.98±1.52 U/ml). Since SmC/growth hormone ratio was significantly more in thyrotoxic pregnant women than in normal pregnant women and euthyroid pregnant women previously treated for hyperthyroidism, and since human placental lactogen (HPL), human chorionic gonadotropin (HCG) and prolactin (PRL) do not crossreact with SmC antibody, it is suggested that excess thyroid hormone during pregnancy results in excessive hepatic somatomedin C production.

Key words

Hyperthyroidism - Pregnancy - TBG - SomatomedinC - GH