The Effect of Hyperosmolarity on Muscle Glycogen Accumulation

J. Li; Julie S. Stillman; J. N. Clore; W. G. Blackard

doi:10.1055/s-2007-1003267

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Horm Metab Res 1992; 24(3): 99-102
DOI: 10.1055/s-2007-1003267

Originals Basic

The Effect of Hyperosmolarity on Muscle Glycogen Accumulation

J. Li² , Julie S. Stillman¹ , J. N. Clore¹ , W. G. Blackard¹

¹Department of Medicine, Medical College of Virginia, Richmond, Virginia, U. S. A.
²Department of Medicine, West China University of Medical Sciences, Chengdu, P. R. China

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Publikationsverlauf

1991

1991

Publikationsdatum:
14. März 2008 (online)

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Summary

Soleus (red) and extensor digitorum longus (white) muscles from Sprague Dawley rats were incubated with 6-¹⁴C-labelled glucose in normal and in hyperosmotic media. Hyperosmolarity decreased 6-¹⁴C-glucose incorporation into muscle glycogen in a dose dependent manner and increased glycolysis and glucose oxidation. Increased glycogenolysis rather than decreased glycogenesis was responsible for the reduction in labelled glycogen accumulation.

Key words

Glycogen - Osmolarity - Muscle