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Horm Metab Res 1992; 24(3): 110-114
DOI: 10.1055/s-2007-1003270
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© Georg Thieme Verlag, Stuttgart · New York

Induction by Cortisol of Aminopeptidases Production from the Human Placenta in Tissue Culture

Y. Yasuda, S. Mizutani, O. Kurauchi, M. Kasugai, O. Narita, Y. Tomoda
  • Department of Obstetrics and Gynaecology, Nagoya University School of Medicine, Nagoya, Japan
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Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

Human placental aminopeptidase M and A and post-proline endopeptidase are known to act as degrading enzymes of bioactive peptides such as angiotensin II, oxytocin and endogenous opioids. We tested the effects of cortisol on the activities of human placental aminopeptidase A and M and post-proline endopeptidase using short-cultured placental tissues. From 34.5 nM to 3.45 μM of cortisol significantly increased the activities of 3 enzymes. Our present data suggest a possible important role of cortisol in the growth of human placenta via induction of placental aminopeptidases.

Key words

Human Placenta - Aminopeptidase A - Aminopeptidase M - Post-proline Endopeptidase - Cortisol