Horm Metab Res 1992; 24(7): 310-312
DOI: 10.1055/s-2007-1003320
Originals Basic

© Georg Thieme Verlag, Stuttgart · New York

Alloxan Diabetes Blocks Noradrenergic Tachyphylaxis in the Isolated Rabbit Kidney - Effects of Insulin

Adriana Costa e Forti, M. C. Fonteles
  • Unidade de Pesquisas Clínicas, Centro de Ciências da Saúde, Fortaleza Ceará, Brazil
Further Information

Publication History

1991

1991

Publication Date:
24 April 2008 (online)

Summary

Normal and alloxan treated diabetic rabbit kidneys were perfused with Krebs-Henseleit solution in a non-recirculating system and the effects of norepinephrine (NOR) 10-6M were tested by infusion of this drug for three subsequent periods of 20 min each, with an interval of 10 min for drug wash-out.

In the control kidneys the infusion of NOR promoted an intense vasoconstriction, which was less intense during the second and the third periods. This was known as tachyphylaxis.

In contrast to the controls, kidneys from diabetic animals did not show tachyphylaxis to NOR, but when insulin was added to the perfusate, tachyphylaxis appeared. Normal kidneys perfused with hyperosmolar solutions show, as in controls, the same phenomenon.

The data presented here demonstrate a defect of adrenergic vascular receptors in alloxan treated kidneys, which can be acutely reversed by insulin. These facts are of importance for the understanding of the vascular disease in diabetes.