Six healthy men were investigated to determine the osmotic efficiency of hypertonic
monosaccharide solutes on the release of plasma arginine vasopressin (AVP).
Twenty percent hypertonic glucose infused at 0.187 mmol/kg body weight/min. over 15
min. increases plasma osmolality but not AVP. In contrast, 20% hypertonic fructose
administered identically obtains an increase in both. An initial 71% rise in AVP concentration
(p < 0.01) occurred 10 min. post-infusion accompanied by a peak in plasma osmolality
and we did not expect AVP to rise by 336% (p < 0.01) 45 minutes after infusion as
plasma osmolality was returning to baseline values. The first increase in plasma AVP
reflects an osmotic efficiency probably resulting from the fact that fructose does
not cross the membrane of osmoreceptor cells. The mechanism of the second and unexpected
increase is discussed, especially the influence of plasma insulin released as a result
of fructose infusion.
Hypertonic Glucose or Fructose - Arginine Vasopressin Release - Normal Humans
