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Horm Metab Res 1991; 23(2): 76-80
DOI: 10.1055/s-2007-1003618
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Serum Bioactive and Immunorective Follicle Stimulating Hormone During Chronic Treatment with Gonadotropin Releasing Hormone Agonist in Elderly Men

H. Matzkin1 , Z. Braf1 , N. Dekel2
  • 1Department of Urology, Ichilov Hospital, Tel-Aviv Medical Center, Tel-Aviv
  • 2Department of Hormone Research, The Weizmann Institute of Science, Rehovot, Israel
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Publication History

1990

1990

Publication Date:
14 March 2008 (online)

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Summary

Chronic administration of GnRH agonists “down regulates” the pituitary and decreases LH and FSH serum levels. Changes in the bioactivity of FSH have not been adequately assessed under such treatment, for lack of a proper test. We examined serum changes under GnRH agonist treatment among 12 healthy elderly men suffering only from benign prostatic hypertrophy, for up to one year, using a modification of a granulosa cell bioassay for the determination of FSH bioactivity. While radioimmunoassay-FSH decreased, we noticed a significant increase in the bioactivity of this hormone. The clinical importance of this increase is discussed.

Key words

FSH - GnRH - FSH-Bioactivity