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Horm Metab Res 1991; 23(4): 168-170
DOI: 10.1055/s-2007-1003643
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Influence of Lysine Acetyl-Salicylate on Glucose and Arginine Stimulated Insulin Release in Man

T. W. van Haeften, T. F. Veneman, E. A. van der Veen
  • Dept. of Endocrinology, Free University Hospital, Amsterdam, The Netherlands
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Publication History

1990

1990

Publication Date:
24 April 2008 (online)

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Summary

In order to determine the influence of acute inhibition of prostaglandin synthesis on insulin release in man, the influence of lysine acetyl-salicylate (0.9 g) on glucose- and arginine-stimulated insulin release was studied in eight volunteers. No significant differences were found in plasma C-peptide levels between the salicylate and the control study days during administration of arginine (0.5 g/kg; 30 min) nor during a hyperglycemic clamp (glucose level 17 mMol/L; 60 minutes). These studies indicate that acute administration of salicylate does not change insulin release in man.

Key words

Lysine Acetyl-Salicylate - Insulin Release