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Horm Metab Res 1991; 23(5): 209-212
DOI: 10.1055/s-2007-1003655
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Sulfonylurea Enhances Insulin-Induced Acetyl Coenzyme A Carboxylase Activity in Rat Adipocytes

M. Matsuda, K. Kaku, M. Aoki, H. Inoue, T. Kaneko
  • The Third Department of Internal Medicine, Yamaguchi University School of Medicine, Kogushi, Ube, Japan
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

The effect of sulfonylurea on the activity of acetyl-coenzyme A carboxylase, a rate limiting enzyme of lipogenesis, was investigated using isolated rat adipocytes. Insulin significantly increased the enzyme activity by 170% of the control level, while glucagon and epinephrine decreased the activity of the enzyme by 53% and 64% of the control, respectively. In the presence of tolbutamide (10-3M)or glibenclamide (10-6M), a significant potentiation of insulin action was found in adipocytes. In addition, sulfonylurea restored the activity of acetyl-CoA carboxylas ereduced by glucagon or epinephrine to the control level. Sulfonylurea enhancement of the acetyl-CoA carboxylase activity may offer one possible explanation for a mechanism of antilipolytic action of the drug in adipocytes.

Key words

Sulfonylurea - Acetyl-CoA Carboxylase - Adipocytes