Secretion and Elimination of Insulin by the In Vitro Perfused Pancreas and Liver of Rats with Thioacetamide-Induced Liver Cirrhosis

H. J. Brömme; T. Zimmermann; W. Blech

doi:10.1055/s-2007-1003669

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Horm Metab Res 1991; 23(6): 262-265
DOI: 10.1055/s-2007-1003669

Originals Basic

Secretion and Elimination of Insulin by the In Vitro Perfused Pancreas and Liver of Rats with Thioacetamide-Induced Liver Cirrhosis

H. J. Brömme¹ , T. Zimmermann² , W. Blech¹

¹Institut für Biochemie der Martin-Luther Universität Halle-Wittenberg, Halle
²Institut für Pathologische Biochemie der Friedrich-Schiller, Jena, Germany

Dedicated to Prof. Dr. Eberhard Hofmann, Leipzig, on occasion of his 60th birthday.

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Publication History

1990

1990

Publication Date:
14 March 2008 (online)

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Summary

Pancreatic secretion and hepatic removal of insulin have been measured in thioacetamide (TAA)-induced compensated rat liver cirrhosis in perfusion experiments. Peripheral plasma concentrations of glucose and insulin were slightly decreased in TAA-treated rats. Pancreatic secretion and hepatic removal of insulin remained unchanged by the TAA-treatment. Thus, even in morphologically and biochemically proven experimental liver cirrhosis, insulin secretion and removal may not be disturbed.

Key words

Insulin - Liver - Pancreas - Rat - Thioacetamide - Cirrhosis