Comparison of Inositol Phosphates Accumulation Induced by Different Effectors in Rat Thyroid Slices

Colette Tertrin-Clary; Marguerite Roy; P. de la Llosa

doi:10.1055/s-2007-1003702

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000025.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Horm Metab Res 1991; 23(8): 365-369
DOI: 10.1055/s-2007-1003702

Originals Basic

Comparison of Inositol Phosphates Accumulation Induced by Different Effectors in Rat Thyroid Slices

Colette Tertrin-Clary, Marguerite Roy, P. de la Llosa

Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

Further Information

Publication History

1990

1991

Publication Date:
14 March 2008 (online)

Also available at

PDF Download Permissions and Reprints

Summary

Rat thyroid slices were submitted to different effectors and hormones in order to investigate their action on the phosphatidylinositol metabolism. Fluoride and vanadate induced a clear increase of the inositol phosphates with half maximal stimulation at 7 mM and 8 mM respectively. The inositol bisphosphate (IP₂) and inositol trisphosphate (IP₃) accumulation induced by vanadate was relatively higher than that observed in the case of fluoride stimulation. Carbachol stimulated also the generation of inositol phosphates with half maximal activation at 2.5 x 10^-6M. In the same conditions, no significant effect on inositol phosphates production could be detected by the action of TSH or TRH.

Key words

Inositol Phosphate - Rat Thyroid - G Protein - Phospholipase C