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DOI: 10.1055/s-2007-1004589
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Octyl-Methoxycinnamate (OMC), an Ultraviolet (UV) Filter, Alters LHRH and Amino Acid Neurotransmitters Release from Hypothalamus of Immature Rats
Publication History
received 22.03.2007
first decision 04.05.2007
accepted 26.06.2007
Publication Date:
19 February 2008 (online)


Abstract
OMC (octyl-methoxycinnamate), is an endocrine disruptor with estrogenic activity, which is used in sunscreen creams as a UV filter. We studied its “in vitro” effects on the hypothalamic release of LHRH as well as on the amino acid neurotransmitter system in immature rats of 15 (prepubertal) and 30 (peripubertal) days of age. OMC decreased the LH-RH release significantly in male and female rats of both age. In male rats OMC increased the release of GABA while in the female ones It diminished the excitatory amino acid aspartate (ASP) and Glutamate (GLU) without modifications in the hypothalamic GABA release. These results suggest that during sexual maturation the inhibitory effect of OMC on LH-RH release appears to be related to its action on the inhibitory and excitatory amino acid neurotransmitters in male and female rats.
Key words
UV filters - hypothalamic LH-RH - amino acid neurotrasmitters - octyl-methoxycinnamate (OMC) - pubertal development