Metabolic Effect at Six and Twelve Months of Cyproterone Acetate (2 mg) Combined with Ethinyl Estradiol (35 μg) in 31 Patients

P. Vexiau; D. Vexiau-Robert; I. Martineau; N. Hardy; J. M. Villette; J. Fiet; G. Cathelineau

doi:10.1055/s-2007-1004893

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1990; 22(4): 241-245
DOI: 10.1055/s-2007-1004893

Clinical

Metabolic Effect at Six and Twelve Months of Cyproterone Acetate (2 mg) Combined with Ethinyl Estradiol (35 μg) in 31 Patients

P. Vexiau¹ , D. Vexiau-Robert¹ , I. Martineau¹ , N. Hardy² , J. M. Villette² , J. Fiet² , G. Cathelineau¹

¹Endocrinology and Diabetology Department, Hôpital Saint Louis, Paris, France
²Biochemistry and Neuroendocrinology Department, Hôpital Saint Louis, Paris, France

Abstract

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Summary

The metabolic effects of cyproterone acetate (2 mg) combined with a new dose level of ethinyl estradiol (35 μg) were studied over a one-year period in 31 patients presenting moderate clinical hyperandrogenism. The following tests were performed before treatment, at 6 and 12 months, an oral glucose tolerance test (OGTT) with measurement of insulinemia, total cholesterol, HDL cholesterol and the LDL + VLDL/ratio HDL, A₁ and B apoproteins. At six months and at one year of treatment, the weight and body mass index (kg/m²) were not modified. Glucose tolerance and insulinemia had not changed significantly at one year. Lipid test results showed an increase in triglycerides, as well as in total and HDL cholesterol levels. However, the LDL + VLDL/HDL and A₁/B apoprotein ratios did not change during the study. We conclude from these results that the new combination does not have any adverse effects on glucose tolerance and has a predominantly estrogenic effect on lipid parameters, characterized by increases in total cholesterol, HDL cholesterol and triglycerides.

Key words

Cyproterone Acetate - Ethinyl Estradiol - Oral Glucose Tolerance Test - Total Cholesterol - HDL Cholesterol - Triglycerides - Apoproteins

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