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Horm Metab Res 1990; 22(10): 537-540
DOI: 10.1055/s-2007-1004966
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Metabolic Profiles and Lipoprotein Lipid Concentrations in Non-Obese and Obese Patients with Polycystic Ovarian Disease

S. Mahabeer, C. Naidoo, R. J. Norman, I. Jialal, K. Reddi, S. M. Joubert
  • MRC Preclinical Diagnostic Chemistry Research Unit, Department of Chemical Pathology, University of Natal Medical School, Durban, South Africa
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

Clinical parameters, androgen status and lipoprotein lipid profiles were assessed in 10 non-obese and 10 obese patients with polycystic ovarian disease (PCOD) and reference subjects matched for age, height and weight. Both obese and non-obese women with PCOD had significantly higher androgen levels when compared to the reference groups. When comparison of lipoprotein lipid profiles were made between groups, non-obese women with PCOD had significantly higher total cholesterol, triglycerides and LDL-cholesterol levels than non-obese reference subjects. Obese PCOD women manifested significantly higher total cholesterol, LDL-cholesterol, cholesterol/HDL, and LDL/HDL values than did obese reference subjects. Correlations between serum androgens and lipoprotein lipid concentrations in PCOD and normal women were unhelpful. Both non-obese and obese patients with PCOD had significantly higher systolic and diastolic blood pressures (BPs) than the reference groups. Thus, both non-obese and obese women with PCOD manifest hyperandrogenaemia which may result in a male pattern of lipoprotein lipid concentrations.

Key words

Androgens - Lipids - Obese and Non-Obese PCOD - Hyperandrogenism - Hyperlipidaemia