The Effect of Exercise on Circulating Immunoreactive Calcitonin in Men

M. E. O'Neill; M. Wilkinson; B. G. Robinson; D. B. McDowall; K. A. Cooper); A. S. Mihailidou; D. B. Frewin; P. Clifton-Bligh; S. N. Hunyor

doi:10.1055/s-2007-1004968

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1990; 22(10): 546-550
DOI: 10.1055/s-2007-1004968

Clinical

The Effect of Exercise on Circulating Immunoreactive Calcitonin in Men

M. E. O'Neill¹ , M. Wilkinson² , B. G. Robinson² , D. B. McDowall² , K. A. Cooper⁴ (formerly¹), A. S. Mihailidou¹ , D. B. Frewin³ , P. Clifton-Bligh² , S. N. Hunyor¹

¹Cardiovascular Research Unit, Dept. of Cardiology, Royal North Shore Hospital, Sydney
²Endocrinology Department, Royal North Shore Hospital, Sydney
³Department of Clinical and Experimental Pharmacology, University of Adelaide, South Australia
⁴Catholic College of Education, North Sydney, Australia

Abstract

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Summary

Moderate-duration exercise increases serum catecholamine and serum calcium levels and might as a result be also expected to increase the levels of circulating serum immunoreactive human calcitonin (HCT). To explore this possibility, HCT was studied during and after moderate duration symptom-limited dynamic exercise in 13 healthy males, mean age 28 ± 6.9 (SD) years. The mean duration of exercise using the Bruce treadmill protocol was 14.1 ± 2.2 (SD) minutes. The mean heart rate (HR) peaked at 185 ± 6 (SD) bpm which was 96.1% of the predicted maximal HR for age. Values for HCT, uncorrected for changes in plasma volume, showed a minimal decrease in the recovery phase, whilst HCT corrected for changes in plasma volume did not alter during exercise or recovery. The serum parathyroid hormone (PTH) also did not change. At peak exercise, uncorrected but not corrected values for plasma noradrenaline, adrenaline and dopamine had increased significantly. Corrected plasma total calcium increased during recovery. In summary, dynamic weight-bearing moderate-duration exercise did not elevate HCT in healthy males.

Key words

Calcitonin - Exercise - Medullary Thyroid Carcinoma - Catecholamines - Parathyroid Hormone - Males

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