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Horm Metab Res 1990; 22(12): 616-618
DOI: 10.1055/s-2007-1004986
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© Georg Thieme Verlag, Stuttgart · New York

Central Activation of Thermogenesis by Prostaglandins: Dependence on CRF

Nancy J. Rothwell
  • Department of Physiological Sciences, University of Manchester, Manchester, United Kingdom
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

Central (intracerebroventricular) injections of PGE2, PGF2α caused dose dependent increases in oxygen consumption (VO2) and colonic temperature in conscious rats. The effects of combined injection of maximal doses of CRF and PGE2 were additive, whereas PGF2α and CRF were not. A CRF receptor antagonist, (α helical CRF 9-41,25 μg icv) markedly inhibited the effects of PGF2α on VO2 and temperature, but did not affect the actions of PGE2. These data indicate that PGF2α and PGE2 stimulate thermogenesis by two different mechanisms, the former depending on CRF release. PGF2α may be involved in the thermogenic actions of interleukin-1β which is also a potent thermogenic agent acting via CRF.

Key words

Thermogenesis - Prostaglandins - CRF