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Horm Metab Res 1990; 22(12): 636-639
DOI: 10.1055/s-2007-1004991
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Circadian Variations of Total Renin, Active Renin, Plasma Renin Activity and Plasma Aldosterone in Clinically Healthy Young Subjects

T. Kawasaki1 , P. Cugini2 , K. Uezono1 , H. Sasaki1 , K. Itoh3 , M. Nishiura4 , K. Shinkawa4
  • 1Institute of Health Science, Kyushu University, Kasuga, Japan
  • 2Endocrine Pathophysiology, University of Rome “La Sapienza”, Rome, Italy
  • 3Nakamura Gakuen College, Fukuoka, Japan
  • 4Daiichi Radioisotope Laboratories Ltd., Tokyo, Japan
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

The direct assay of total renin (TRC) and active renin concentration (ARC) is a reality due to the availability of monoclonal antibodies against human renin. Because of this, a study has been performed in order to assess the circadian rhythmicity of TRC and ARC. The study was extended to plasma renin activity (PRA) and plasma aldosterone concentration (PAC) for a more complete assessment of the renin-angiotensin-aldosterone system (RAAS). Twelve clinically healthy subjects (6 males and 6 females, age from 20 to 25 years) volunteered for this study. Time-qualified data series were analysed by means of chronobiological procedures in order to validate the circadian rhythm and to correlate the sinusoidal profiles. The circadian rhythm was validated at a high significance for TRC, ARC, PRA and at a borderline significance for PAC. The periodic oscillations were significantly correlated, demonstrating that TRC, ARC, PRA and PAC cycles oscillate in synchronism during the 24-hour span.

Key words

Circadian Rhythm - Total Renin Concentration - Active Renin Concentration - Renin-Angiotensin-Aldosterone System - Cosinor Analysis