Die perkutane Koronarintervention (PCI) ist ein sicheres und effektives Verfahren
zur Wiederherstellung der Myokardperfusion. Allerdings steigt mit zunehmendem Alter
das Komplikationsrisiko des Verfahrens. Vorteilhaft kann das invasive Vorgehen beim
akuten Koronarsyndrom dennoch auch bei älteren Patienten sein - insbesondere wenn
ein ST-Strecken-Hebungsinfarkt vorliegt -, während bei der stabilen koronaren Herzkrankheit
eine konservative der invasiven Therapie bezüglich der Prognose ebenbürtig ist. Bei
der individuellen Entscheidung für oder gegen eine interventionelle Behandlung sollten
neben dem biologischen Alter, die Begleiterkrankungen sowie die Koronaranatomie eines
jeden Patienten mit in die Entscheidung einfließen.
Percutaneous coronary intervention (PCI) is a safe and effective procedure to reconstitute
myocardial perfusion. With advancing age patients face a higher risk for complications
of PCI. In elderly patients with acute coronary syndromes especially those with STEMI
an invasive strategy with PCI improves the prognosis, whereas in stable coronary heart
disease a conservative approach is equally effective. Individual decisions in favour
of or contrary to an interventional treatment should be based on the biological age,
concomitant diseases and coronary anatomy of the patient.
Key words
percutaneous coronary intervention - age - complications - acute coronary syndromes
Literatur
1
Antmann EM, Anbe DT, Armstrong PW. et al. .
ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction
- executive summary: a report of the American College of Cardiology/American Heart
Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999
Guidelines for the Management of Patients With Acute Myocardial Infarction).
Circulation.
2004;
110
2
Bach RG, Cannon CP, Weintraub WS. et al. .
The effect of routine, early invasive management on outcome for elderly patients with
non-ST-segment elevation acute coronary syndromes.
Ann Intern Med.
2004;
141
186-195
3
Batchelor WB, Anstrom KJ, Muhlbaier LH. et al. .
Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions:
results in 7,472 octogenarians. National Cardiovascular Network Collaboration.
J Am Coll Cardiol.
2000;
36
723-730
4
Braunwald E, Antman EM, Beasley JW. et al. .
ACC/AHA guideline update for the management of patients with unstable angina and non-ST-segment
elevation myocardial infarction - 2002: summary article: a report of the American
College of Cardiology/ American Heart Association Task Force on Practice Guidelines
(Committee on the Management of Patients With Unstable Angina).
Circulation.
2002;
106
1893-1900
5
De Servi S, Cavallini C, Dellavalle A. et al. .
Non-ST-Elevation acute coronary syndrome in the elderly: treatment strategies and
30-day outcome.
Am Heart.
2004;
147
830-836
6
Feldman DN, Gade CL, Slotwiner AJ. et al. .
New York State Angioplasty. Comparison of outcomes of percutaneous coronary interventions
in patients of three age groups (< 60, 60 to 80, and > 80 years) (from the New York
State Angioplasty Registry).
Am J Cardiol.
2006;
98
1334-1339
7
Graham MM, Ghali WA, Faris PD. et al. .
Survival after coronary revascularization in the elderly.
Circulation.
2002;
105
2378-2384
8 Grines C.. TCT 2005
9
Metha RH, Granger CB, Alexander KP. et al. .
Reperfusion strategies for acute myocardial infarction in the elderly: benefits and
risks.
J Am Coll Cardiol.
2005;
45
471-478
10
Pfisterer M, Buser P, Osswald S. et al. .
Outcome of elderly patients with chronic symptomatic coronary artery disease with
an invasive vs optimized medical treatment strategy: one-year results of the randomized
TIME trial.
JAMA.
2003;
289
1117-1123
11
Silber S, Albertsson P, Avilés FF. et al. .
Guidelines for percutaneous coronary interventions. The Task Force for Percutaneous
Coronary Interventions of the European Society of Cardiology.
Eur Heart J.
2005;
26
804-847
12
Yusuf S, Flather M, Pogue J. et al. .
Variations between countries in invasive cardiac procedures and outcomes in patients
with suspected unstable angina or myocardial infarction without initial ST elevation.
OASIS (Organisation to Assess Strategies for Ischaemic Syndromes) Registry Investigators.
Lancet.
1998;
352
507-514
13
Zahn R, Schiele R, Schneider S. et al. .
Primary angioplasty versus intravenous thrombolysis in acute myocardial infarction:
can we define subgroups of patients benefiting most from primary angioplasty? Results
from the pooled data of the Maximal Individual Therapy in Acute Myocardial Infarction
Registry and the Myocardial Infarction Registry.
J Am Coll Cardiol.
2001;
37
1827-1835
14
Zijlstra F, Patel A, Jones M. et al. .
Clinical characteristics and outcome of patients with early (< 2 h), intermediate
(2-4 h) and late (> 4 h) presentation treated by primary coronary angioplasty or thrombolytic
therapy for acute myocardial infarction.
Eur Heart J.
2002;
23
550-557
15
Zeymer U, Gitt A, Winkler R. et al. .
Sterblichkeit bei über 75-jährigen Patienten mit akutem ST-Hebungsmyokardinfarkt im
klinischen Alltag.
Dtsch Med Wochenschr.
2005;
130
633-636
16
Zeymer U, Zahn R, Hochadel M. et al. .
Indications and complications of invasive diagnostic procedures and percutaneous coronary
interventions in the year 2003. Results of the quality control registry of the Arbeitsgemeinschaft
Leitende Kardiologische Krankenhausarzte (ALKK).
Z Kardiol.
2005;
94
392-398
1 Trial of Invasive versus Medical therapy in Elderly patients
2 Treat Angina with Aggrastat and determine Cost of Therapy with an Invasive or Conservative
Strategy - Thrombolysis In Myocardial Infarction
3 Maximal Individual Therapy in Acute Myocardial Infarction
4 Primary Angioplasty in Myocardial Infarction in the elderly
5 Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausärzte
Korrespondenz
PD Dr. Uwe Zeymer
Klinik für Kardiologie Medizinische Klinik B Herzzentrum Ludwigshafen
Bremserstraße 79
67063 Ludwigshafen
eMail: uwe.zeymer@t-online.de