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J Reconstr Microsurg 1997; 13(3): 193-197
DOI: 10.1055/s-2007-1006404
ORIGINAL ARTICLE

© 1997 by Thieme Medical Publishers, Inc.

The Significance of Tumor Necrosis Factor (TNF) Levels for Rejection of Joint Allograft

Hiroshi Watanabe, Koki Nagasawa, Yoshiki Hamada, Tadahito Toshima, Yoshitaka Sakano, Noriya Akamatsu
  • Department of Orthopedic Surgery, Yamanashi Medical College, Japan
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Publication History

Accepted for publication 1996

Publication Date:
08 March 2008 (online)

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ABSTRACT

This paper describes the efficacy of utilizing Tumor Necrosis Factor -α (TNF) as a detectable parameter of acute rejection after bone allografts. The authors used a bone-joint allograft model, transferring vas-cularized allograft knee joints across a major histocompatibility barrier, using three groups of rats divided into controls, non-immunosuppressed, and immunosuppressed with cyclosporine. The paper supplies preliminary information suggesting that TNF may be a marker for early bone-joint allograft rejection.