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DOI: 10.1055/s-2007-1006414
© 1997 by Thieme Medical Publishers, Inc.
Blood Flow and Microcirculatory Changes in an Ischemia-Reperfusion Injury Model: Experimental Study in the Rabbit
Publikationsverlauf
Accepted for publication 1997
Publikationsdatum:
08. März 2008 (online)
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ABSTRACT
This is the first in a series of studies designed to investigate the simultaneous changes in blood flow and microcirculation in an island flap during ischemia, in an ischemia-reperfusion model in the rabbit. An island groin flap based on the inferior epigastric vessels was harvested in 17 rabbits. The flap was rendered ischemic for 4 (n = 4), 6 (n = 4), and 16 (n = 9) hr by applying a microvascular clamp to both the inferior epigastric artery and vein. The blood flow in the epigastric artery and the microcirculation of the flap were monitored for 1 hr before the ischemia and for 3 hr after the ischemia period, using a transonic Doppler and a laser Doppler, respectively.
Both the blood flow and the microcirculation of the flap were found significantly increased immediately after the ischemia in the 4- and 6-hr ischemia groups, compared to the pre-ischemic values. In the same groups, blood flow and microcirculation remained elevated over pre-ischemic levels, indicating a hyperemic response. In the 16-hr ischemic group, blood flow and microcirculation values remained significantly lower than the pre-ischemic readings at all points in time, demonstrating ischemia-reperfusion injury.