Thrombosis in an Ischemia-Reperfusion Injury Flap Model: Is Vessel Anastomosis a Factor?

Sangmyun Cha; Mark A. Schusterman; Douglas M. Cromeens

doi:10.1055/s-2007-1006449

Journal of Reconstructive Microsurgery, Table of Contents

J Reconstr Microsurg 1996; 12(1): 27-30
DOI: 10.1055/s-2007-1006449

ORIGINAL ARTICLE

Thrombosis in an Ischemia-Reperfusion Injury Flap Model: Is Vessel Anastomosis a Factor?

Sangmyun Cha, Mark A. Schusterman, Douglas M. Cromeens

Departments of Plastic Surgery and Veterinary Medicine and Surgery, University of Texas M.D. Anderson Cancer Center, Houston, Texas

Abstract

ABSTRACT

This study was undertaken to elucidate the possible contribution of vessel anastomosis to the incidence of vessel thrombosis in an ischemia-reperfusion injury flap model in rabbits. Bilateral groin flaps were elevated on isolated vascular pedicles and rendered ischemic for 6 (n = 11), 8 (n = 5), 15.5 (n = 5), or 24 hr (n = 8). After the ischemic episode, an arterial anastomosis was performed on one side, and then perfusion was reestablished on both sides. Although the incidence of thrombosis increased with the interval of ischemia, there was no statistically significant difference in thrombosis rate between the two sides for any of the ischemia intervals studied. The authors conclude that the presence of an arterial anastomosis does not increase the rate of vessel thrombosis in flaps after primary ischemia-reperfusion injury in the rabbit model.

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