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J Reconstr Microsurg 1995; 11(2): 93-98
DOI: 10.1055/s-2007-1006515
DOI: 10.1055/s-2007-1006515
ORIGINAL ARTICLE
© 1995 by Thieme Medical Publishers, Inc.
Continuous Alteration of the Internal Milieu of a Nerve-Guide Chamber Using an Osmotic Pump and Internal Exhaust System
Further Information
Publication History
Accepted for publication 1994
Publication Date:
08 March 2008 (online)
![](https://www.thieme-connect.de/media/jrm/199502/lookinside/thumbnails/10.1055-s-2007-1006515-1.jpg)
ABSTRACT
The use of non-neural conduits to span gaps in regenerating peripheral nerves has been noted in the literature for many years. An intriguing addition to this so-called entubulation repair method is the continuous instillation of neuronotrophic or growth factors into the lumen of the guide to bathe the regenerating nerve. A model is presented which uses an osmotic pump that supplies a constant, reproducible amount of solution into the lumen of a nerve guide without disrupting the regeneration process.