Recovery after Delayed Nerve Repair: Influence of a Pharmacologic Adjunct in a Primate Model

Marie A. Badalamente; Lawrence C. Hurst; Alfred Stracher

doi:10.1055/s-2007-1006724

Journal of Reconstructive Microsurgery, Table of Contents

J Reconstr Microsurg 1992; 8(5): 391-397
DOI: 10.1055/s-2007-1006724

ORIGINAL ARTICLE

Recovery after Delayed Nerve Repair: Influence of a Pharmacologic Adjunct in a Primate Model

Marie A. Badalamente, Lawrence C. Hurst, Alfred Stracher

Department of Orthopaedics, School of Medicine, State University of New York, Stony Brook, NY, and Department of Biochemistry, School of Medicine, State University of New York, Brooklyn, NY

Abstract

ABSTRACT

Inhibition of calpains in skeletal muscle by the tripeptide, leupeptin, after median-nerve transection in the mid-forearm and a delayed nerve repair of 3-weeks duration, was studied in a primate (Cebus apella) model. Results indicated that leupeptin facilitates axon regrowth and neuromuscular recovery after delayed nerve repair. Toxicologic testing showed that leupeptin, administered at 18 mg/kg intramuscularly, twice daily for 24 weeks after delayed nerve repair, did not adversely affect hematology, clotting, blood chemistry, or echocardiogram profiles. These data indicate that leupeptin is an effective and safe adjunct to delayed nerve repair.

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