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J Reconstr Microsurg 1991; 7(1): 9-12
DOI: 10.1055/s-2007-1006757
ORIGINAL ARTICLE

© 1991 by Thieme Medical Publishers, Inc.

Regeneration of Autologous and Allogenic Nerve Grafts in a Rat Genetic Model: Preliminary Report

E. Schaller, F. Lassner, M. Becker, G. F. Walter, A. Berger
  • Clinic of Plastic and Reconstructive Surgery and Institute of Neuropathology, Medical School of Hannover
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Publication History

Accepted for publication 990

Publication Date:
08 March 2008 (online)

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ABSTRACT

The authors report observations concerning rejection and regeneration processes of allogenic peripheral neural tissue, depending on different genetic mismatches in a rat model. Five groups representing different rat strains (n = 100) were subjected to orthotopic grafting of 2.5-cm segments of sciatic nerve. Combinations represented different genetic barriers, including the Major Histocompatibility Complex (MHC), a non-MHC,a subgroup (A) of the MHC, a group representing MHC plus non-MHC,andan autologous control group. Animals were examined after one, two, and 12 weeks; additional evaluations in some of the experimental groups were done at six and eight weeks. Regeneration in varying degrees was evident in all groups at 12 weeks.