J Reconstr Microsurg 1987; 3(2): 147-151
DOI: 10.1055/s-2007-1006978
ORIGINAL ARTICLE

© 1987 by Thieme Medical Publishers, Inc.

Relief of Blood-Induced Arterial Vasospasm by Pharmacologic Solutions

Sheng-Mou Hou, Anthony V. Seaber, James R. Urbaniak
  • Orthopaedic Research Laboratories, Duke University Medical Center, Durham, North Carolina
Weitere Informationen

Publikationsverlauf

Accepted for publication 1986

Publikationsdatum:
08. März 2008 (online)

ABSTRACT

A partially amputated rat hind limb model was used to evaluate the potency of 1 percent, 2 percent, and 20 percent Xylocaine, 0.3 percent papaverine, and normal saline in both the treatment and prevention of blood-induced arterial spasm. Direct application of blood to the femoral artery was shown to produce a 60 percent reduction in limb perfusion. The 0.3 percent papaverine and 20 percent Xylocaine solutions were statistically superior to normal saline and the lower Xylocaine concentrations in their ability to relieve the blood-induced vasospasm and prevent further spasm. Normal saline, 1 percent Xylocaine, and 2 percent Xylocaine showed no preventive effect against blood-induced spasm. These findings emphasize the importance of good hemostasis in microsurgery, and simplify the choice of an effective spasmolytic agent.