Effects of Alpha-2 Adrenoreceptor Blockade by Yohimbine on the Hormonal Response to Hypoglycaemic Stress in Normal Man

R. C. Cuneo; J. H. Livesey; M. G. Nicholls; E. A. Espiner; R. A. Donald

doi:10.1055/s-2007-1009143

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1989; 21(1): 33-36
DOI: 10.1055/s-2007-1009143

Clinical

Effects of Alpha-2 Adrenoreceptor Blockade by Yohimbine on the Hormonal Response to Hypoglycaemic Stress in Normal Man

R. C. Cuneo, J. H. Livesey, M. G. Nicholls, E. A. Espiner, R. A. Donald

Department of Endocrinology, The Princess Margaret Hospital, Christchurch, New Zealand

Abstract

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Summary

In order to evaluate the effect of alpha-2 adrenoreceptor blockade on the ACTH response to insulin-induced hypoglycaemia, six normal men were studied with and without yohimbine (30 mg p.o.) premedication. Despite a similar hypoglycaemic stimulus and significant suppression of the growth hormone response (P < 0.05), no change was observed in basal or stimulated plasma ACTH, cortisol, arginine vasopressin (AVP) or prolactin responses following yohimbine. We conclude that alpha-2 adrenoreceptor blockade with yohimbine does not significantly affect the ACTH response to hypoglycaemia in man.

Key-Words

Alpha-2 Adrenoreceptors - ACTH - Yohimbine - Insulin-Hypoglycaemia - Growth Hormone

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