Zinc: An Inhibitor of Prolactin (PRL) Secretion in Humans

J. Brandão Néto; B. B. de Mendonça; T. Shuhama; J. S. Marchini; G. Madureira; W. P. Pimenta; M. T. T. Tornero

doi:10.1055/s-2007-1009191

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1989; 21(4): 203-206
DOI: 10.1055/s-2007-1009191

Clinical

Zinc: An Inhibitor of Prolactin (PRL) Secretion in Humans

J. Brandão Néto¹ , B. B. de Mendonça² , T. Shuhama³ , J. S. Marchini¹ , G. Madureira² , W. P. Pimenta¹ , M. T. T. Tornero⁴

¹Endocrine-Metabolism Units, Departments of Internal Medicine, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil
²Endocrine-Metabolism Units, Departments of Internal Medicine, Universidade de São Paulo (USP), Botucatu, São Paulo, Brazil
³Analytical Chemistry Laboratory, Department of Physical Chemistry, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Botucatu, São Paulo, Brazil
⁴Department of Biostatistic, Institute of Bioscience, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil

Abstract

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Summary

The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women. Blood samples were collected at 10 and 30-min intervals over a period of 120 min after two basal times (-30 and 0 min). PRL concentrations significantly fell below basal levels in all subjects in response to the increase in plasma zinc levels, as compared to the controls.

These results suggest that acute hyperzincemia can inhibit basal PRL secretion in normal individuals.

Key-Words

Zinc - Prolactin (PRL) Release - Hypothalamus - Hypophysis - Normal Individuals

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