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Horm Metab Res 1989; 21(7): 359-361
DOI: 10.1055/s-2007-1009237
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© Georg Thieme Verlag, Stuttgart · New York

Effects of Experimental Hypo- and Hyperthyroidism on Hepatic Long-Chain Fatty Acyl-CoA Synthetase and Hydrolase

A. Q. Dang, F. H. Faas, W. J. Carter
  • John L. McClellan Memorial Veterans Hospital and Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.
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Publication History

1988

1988

Publication Date:
14 March 2008 (online)

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Summary

The effects of T3 treatment and thyroidectomy on rat liver microsomal long-chain fatty acyl-CoA (LCFA-CoA) synthetase and LCFA-CoA hydrolase activities were determined. Hyperthyroid rats had a 36-42% decrease in LCFA-CoA synthetase with no change in hydrolase activity. This may contribute to the redirection of fatty acids from esterification to oxidation reactions in hyperthyroidism. Thyroidectomized rats had a 40-44% decrease in synthetase and a 27-42% decrease in LCFA-CoA hydrolase activity. The decrease in both LCFA-CoA synthetase and hydrolase activities in hypothyroidism may indicate that the LCFA-CoA turnover in this futile cycle is decreased in the liver.

Key-Words

Long Chain Fatty Acyl-CoA Synthetase - Long Chain Fatty Acyl-CoA Hydrolase - T3 Treatment - Hyperthyroidism - Thyroidectomy - Hypothyroidism