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Horm Metab Res 1989; 21(7): 366-368
DOI: 10.1055/s-2007-1009239
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© Georg Thieme Verlag, Stuttgart · New York

Effects of Bestatin on Intrauterine Growth of Rat Fetuses

M. Furuhashi, S. Mizutani, O. Kurauchi, M. Kasugai, Y. Tomoda
  • Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan
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Publication History

1988

1988

Publication Date:
14 March 2008 (online)

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Summary

Pregnant Wister rats were injected with bestatin, a specific inhibitor of aminopeptidase M. Placental aminopeptidase M activity was inhibited by injection of bestatin, and fetal body weight was statistically lower than that in the saline-injected or control group. Our present data suggest that placental aminopeptidase M plays an important role in fetal growth.

Key-Words

Intrauterine Growth Retardation (IUGR) - Aminopeptidase M - Alkaline Phosphatase - Placenta