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Horm Metab Res 1989; 21(10): 577-580
DOI: 10.1055/s-2007-1009291
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Pharmacokinetics of 24,25-Dihydroxyvitamin D3 in Humans

M. Jongen, W. J. F. van der Vijgh, J. C. Netelenbos, G. J. Postma, P. Lips
  • Research Laboratory, Department of Internal Medicine, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands
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Publikationsverlauf

1988

1989

Publikationsdatum:
24. April 2008 (online)

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Summary

Pharmacokinetic properties of pharmacological doses of 24,25-dihydroxyvitamin-D3 [24,25(OH)2D3] were determined in healthy volunteers. Four male subjects received 25 μg of 24,25(OH)2D3 as an intravenous bolus injection. Plasma concentrations of 24,25(OH)2D3, 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D were monitored during 14 days. In addition, serum ionized calcium, total calcium, inorganic phosphate, albumin, creatinine and intact hPTH(1-84) were measured during 14 days. The concentration-time curve of 24,25(OH)2D3 could be described by a two-exponential curve with half-lives of 3.0 ± 0.9 hrs and 8.2 ± 2.9 days (mean ± SD). The volume of distribution was 0.19 ± 0.02 liters/kg. None of the mentioned biochemical parameters, except serum 24,25(OH)2D3, changed markedly. In 18 subjects suffering from primary hyperparathyroidism, taking 25 μg of 24,25(OH)2D3 daily during three months, an average plateau level of 39 ± 12 nmol/l of serum was observed. Bioavailability as estimated from this plateau level was approximately 70%.

Key-Words

24,25-Dihydroxyvitamin-D3 - Pharmacokinetics - Intravenous Administration - Healthy Subjects - Primary Hyperparathyroidism