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Horm Metab Res 1989; 21(12): 649-651
DOI: 10.1055/s-2007-1009311
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© Georg Thieme Verlag, Stuttgart · New York

The Effect of Gossypol on Serum Lipoproteins of Adult Rats

A. Obeidy1 , I. A. Fities2 , D. S. Sheriff3
  • 1Department of Zoology, Garyovnis University, Benghazi, Libya
  • 2Department of Histology, Al Arab Medical University, Benghazi, Libya
  • 3Department of Biochemistry, Al Arab Medical University, Benghazi, Libya
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Publication History

1988

1989

Publication Date:
14 March 2008 (online)

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Summary

It has been shown that gossypol treatment brings about marked changes in plasma lipoproteins of certain species causing a marked fall in total cholesterol and LDL-cholesterol levels. Using Helena electrophoretic system the lipoprotein pattern in serum of adult rats treated with gossypol was studied. Gossypol treatment for 1 day and 7 days continuously did bring about changes in serum lipoprotein profile. A marked increase in VLDL-cholesterol and fall in LDL-cholesterol was observed in rats treated with gossypol which was more pronounced in the 7 days treated group. It did not bring about any marked change in total cholesterol level. It did cause an increase in serum triglyceride level. Heparin injection which brought about a fall in VLDL-cholesterol with a concomitant increase in HDL-cholesterol in control rats did not elicit changes in gossypol-treated rats. Thus, gossypol treatment appears to alter serum lipoprotein metabolism in rats also.

Key-Words

Gossypol - Adult Rats - Serum Lipoproteins - VLDL Metabolism