Download PDF
Horm Metab Res 1989; 21(12): 658-660
DOI: 10.1055/s-2007-1009313
Originals Basic

© Georg Thieme Verlag, Stuttgart · New York

Effects of H1 and H2 Histamine Receptor Antagonists on Positive Feed-Back Effect of Estrogen on LH in Prepubertal Female Rats

J. A. Moguilevsky, B. Szwarcfarb, M. R. Faigón, J. Paolini, P. Scacchi
  • Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Further Information

Publication History

1988

1989

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The aim of the present study was to determine whether histaminergic central mechanisms which exert a well known effect on gonadotrophin secretion are involved in the development of the positive feed-back effect of estrogen-progesterone (E-P) on LH secretion that normally occurs in female rats about 20-22 days old.days of age.

The administration of histamine H2 (cimetidine and ranitidine) or H1 (diphenhydramine) receptor blocking agents did not modify the onset of the LH release response to E-P. Nevertheless cimetidine, ranitidine and diphenhydramine potentiated the LH release induced by ovarian steroids at 23 days of age.

These results appear to indicate that histaminergic pathways are involved in the magnitude of the LH response to E-P in prepubertal female rats rather than in the maturation of this mechanism.

Key-Words

Histamine Receptors - Gonadotrophin Control - LH Release - Positive Feed-Back