Download PDF
Horm Metab Res 1989; 21(12): 666-668
DOI: 10.1055/s-2007-1009315
Originals Basic

© Georg Thieme Verlag, Stuttgart · New York

Structure-Activity Relationship of Calcitonin Gene Related Peptide

K. Morita, I. Kato, T. Uzawa, M. Hori, T. Noda
  • Research Laboratory, Toyo Jozo Co., Ltd., Ohito, Tagata, Shizuoka, Japan
Further Information

Publication History

1988

1989

Publication Date:
14 March 2008 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

Chicken, human(α) CGRPs and their analogues were synthesized to investigate the relationship between structure and serum calcium and phosphate lowering effects. The native hormones contain 37 amino acid residues with only four positions (3, 14, 15 and 23) that differ. Chicken CGRP exhibits stronger and longer lasting activities than the human hormone. A chicken CGRP analogue with replacement of Asp at position 14 by Gly (as in human CGRP) showed great reduction of activity. The converse replacement of Gly at position 14 by Asp in human CGRP enhanced this analogue activity. Among the synthetic analogues, des-1-Ala-des-α-amino chicken CGRP, exhibited the most potent and long lasting biological activity.

Key-Words

CGRPs - Metabolites - Analogues - Hypocalcemic Activity