Continuous 5-Fluorouracil Infusion Causing Acute Gastric Mucosal Lesions

K. Suda; T. Seki; Y. Kano; M. Sasagawa

doi:10.1055/s-2007-1010352

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Endoscopy 1993; 25(6): 426-427
DOI: 10.1055/s-2007-1010352

Continuous 5-Fluorouracil Infusion Causing Acute Gastric Mucosal Lesions

K. Suda¹ , T. Seki² , Y. Kano¹ , M. Sasagawa²

¹Department of Medical Oncology, Tochigi Cancer Center, Utsunomiya, Japan
²Department of Diagnostic Imaging, Tochigi Cancer Center, Utsunomiya, Japan

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Publication Date:
17 March 2008 (online)

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Abstract

A 59-year-old woman with advanced gastric cancer was treated with continuous 5-fluorouracil infusion for thirty-five days. Endoscopy of the upper gastrointestinal tract was performed due to continuing nausea seven days after the cessation of 5-fluorouracil infusion and revealed multiple erosions in the antrum which were absent before chemotherapy. Continuous 5-fluorouracil infusion was probably the cause of acute gastric mucosal lesions and should be included in the differential diagnosis of dyspepsia in 5-FU-treated patients.