Effect of Insulin Deficiency on Low Density Lipoprotein Metabolism in Rabbits

A. Golay; L. Zech; M.-Z. Shi; Y.-AM Chiou; G. M. Reaven; Y.-DI Chen

doi:10.1055/s-2007-1010737

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1988; 20(1): 11-14
DOI: 10.1055/s-2007-1010737

ORIGINALS

Basic
© Georg Thieme Verlag, Stuttgart · New York

Effect of Insulin Deficiency on Low Density Lipoprotein Metabolism in Rabbits

A. Golay, L. Zech, M.-Z. Shi, Y.-A. M. Chiou, G. M. Reaven, Y.-D. I. Chen

Department of Medicine, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Palo Alto, U.S.A.

Abstract

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Summary

These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, ¹²⁵I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of ¹²⁵I-LDL. These data demonstrate that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.

Key-Words

LDL Catabolism - Cholesterol - Alloxan-Induced Diabetes - ¹²⁵I-LDL Turnover - Insulin Deficiency

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