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DOI: 10.1055/s-2007-1010769
© Georg Thieme Verlag, Stuttgart · New York
Changes in Phosphate Do Not Affect Insulin Release from Isolated Mouse Islets of Langerhans
Publication History
1987
1987
Publication Date:
14 March 2008 (online)
![](https://www.thieme-connect.de/media/hmr/198802/lookinside/thumbnails/10.1055-s-2007-1010769-1.jpg)
Summary
Phosphate affects glucose tolerance, insulin release and peripheral insulin sensitivity. In the present study moderate changes in the phosphate concentration of the incubation medium from 0.3 to 2 mmol/l (i.e., within the physiological range) did not affect insulin release from isolated mouse islets In vitro. In addition, the vitamin-D status of the animals had no effect on the glucose-stimulated insulin response in the different phosphate concentrations.
Therefore these data indicate that the impaired glucose tolerance seen in hypophosphatemic states is not due to a direct effect of phosphorus levels on the insulin-releasing B-cell.
Key-Words
Phosphorus - Vitamin D3 - Islets of Langerhans - Hypophosphatemia - Mouse