Changes in Phosphate Do Not Affect Insulin Release from Isolated Mouse Islets of Langerhans

Summary

Phosphate affects glucose tolerance, insulin release and peripheral insulin sensitivity. In the present study moderate changes in the phosphate concentration of the incubation medium from 0.3 to 2 mmol/l (i.e., within the physiological range) did not affect insulin release from isolated mouse islets In vitro. In addition, the vitamin-D status of the animals had no effect on the glucose-stimulated insulin response in the different phosphate concentrations.

Therefore these data indicate that the impaired glucose tolerance seen in hypophosphatemic states is not due to a direct effect of phosphorus levels on the insulin-releasing B-cell.

Key-Words

Phosphorus - Vitamin D₃ - Islets of Langerhans - Hypophosphatemia - Mouse