Horm Metab Res 1988; 20(4): 218-220
DOI: 10.1055/s-2007-1010797
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Effect of Ethanol and Linoleic Acid on Changes in Biliary Excretion of Iodothyronines Possibly Related to Thyroxine Deiodination in Rat Liver

P. Langer, O. Földes, K. Gschendtová
  • Institute of Experimental Endocrinology, Center of Physiological Sciences SAV, Bratislava, Czechoslovakia
Further Information

Publication History

1987

1987

Publication Date:
14 March 2008 (online)

Summary

Groups of male rats weighing about 350 g were inserted polyethylene tubings into bile duct and femoral vein under pentobarbital anesthesia. Several iodothyronines (i.e. T4, T3, rT3, 3,5-T2, 3,3′-T2 and 3′,5′-T2) were estimated in 2-hr portions of bile with the aid of specific radioimmunoassay. After the infusion of ethanol significant increase of 3′,5′-T2 excretion was found. It was concluded that both ethanol and unsaturated fatty acids may inhibit 5′-monodeiodination in the liver and that unsaturated nonesterified fatty acids may exert such effect even when administered intravenously without underlying metabolic disorders.