Summary
Groups of male rats weighing about 350 g were inserted polyethylene tubings into bile duct and femoral vein under pentobarbital anesthesia. Several iodothyronines (i.e. T4, T3, rT3, 3,5-T2, 3,3′-T2 and 3′,5′-T2) were estimated in 2-hr portions of bile with the aid of specific radioimmunoassay. After the infusion of ethanol significant increase of 3′,5′-T2 excretion was found. It was concluded that both ethanol and unsaturated fatty acids may inhibit 5′-monodeiodination in the liver and that unsaturated nonesterified fatty acids may exert such effect even when administered intravenously without underlying metabolic disorders.
Key-Words
Liver
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Thyroxine Metabolism
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Bile
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Ethanol
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Nonesterified Fatty Acids
